Table 1.
Age-adjusted incidence of HPV-related cancers among females aged 15-34 years in the United States during 2002-2006 and 2015-2019
| Characteristics by age group | No. of cases |
Incidence (per 1 000 000 person-years) (95% CI)a |
Rate ratio vs 2002-2006 | ||
|---|---|---|---|---|---|
| 2002-2006 | 2015-2019 | 2002-2006 | 2015-2019 | ||
| Age group | |||||
| 15-24 y | |||||
| HPV-related cancersb | 1163 | 428 | 11.13 (10.5 to 11.79) | 3.85 (3.5 to 4.24) | 0.35 (0.31 to 0.39) |
| Vulvar squamous cell carcinoma | 314 | 60 | 3.02 (2.7 to 3.38) | 0.55 (0.42 to 0.7) | 0.18 (0.13 to 0.24) |
| Cervical carcinoma | 790 | 343 | 7.54 (7.02 to 8.08) | 3.08 (2.76 to 3.43) | 0.41 (0.36 to 0.46) |
| 25-34 y | |||||
| HPV-related cancers | 9853 | 9595 | 101.92 (99.92 to 103.95) | 88.99 (87.22 to 90.79) | 0.87 (0.85 to 0.90) |
| Oropharyngeal squamous cell carcinoma | 141 | 138 | 1.46 (1.23 to 1.73) | 1.27 (1.07 to 1.51) | 0.87 (0.68 to 1.11) |
| Anal and rectal squamous cell carcinoma | 158 | 193 | 1.64 (1.39 to 1.91) | 1.8 (1.56 to 2.08) | 1.10 (0.89 to 1.37) |
| Vulvar squamous cell carcinoma | 1052 | 627 | 10.89 (10.24 to 11.57) | 5.84 (5.39 to 6.31) | 0.54 (0.48 to 0.59) |
| Vaginal squamous cell carcinoma | 93 | 67 | 0.96 (0.77 to 1.18) | 0.63 (0.48 to 0.79) | 0.65 (0.47 to 0.90) |
| Cervical carcinoma | 8409 | 8570 | 86.97 (85.12 to 88.85) | 79.45 (77.77 to 81.15) | 0.91 (0.89 to 0.94) |
a Annual incidence rates were calculated as the number of cases per 1 000 000 persons and were age-adjusted to the 2000 US standard population. Differences in age-adjusted rates were evaluated using rate ratios (RRs) and the corresponding 95% confidence intervals (CIs). The Tiwari method was used to determine the confidence intervals. HPV = human papillomavirus.
b Definitions of HPV-related cancer are as follows. All are histologically confirmed.
Oropharyngeal squamous cell carcinoma: the International Classification of Disease for Oncology, Third Edition (ICD-O-3) site codes: C01.9, C02.4, C02.8, C05.1, C05.2, C09.0, C09.1, C09.8, C09.9, C10.0-C10.4, C10.8, C10.9, C14.0, C14.2, and C14.8.
ICD-O-3 histologic codes 8050-8086 and 8120-8131.
Anal and rectal squamous cell carcinoma: ICD-O-3 site codes C20.9, C21.0-C21.2, C21.8. ICD-O-3 histologic codes 8050-8084 and 8120-8131.
Vulvar squamous cell carcinoma: ICD-O-3 site codes C51.0-C51.2, C51.8, and C51.9.
ICD-O-3 histologic codes 8050-8084 and 8120-8131. Only female patients are included.
Vaginal squamous cell carcinoma: ICD-O-3 site code C52.9.
ICD-O-3 histologic codes 8050-8084 and 8120-8131. Only female patients are included.
Cervical carcinoma: ICD-O-3 site code C53.0, C53.1, C53.8, and C53.9.
ICD-O-3 histologic codes 8010-8671 and 8940-8941. Only female patients are included.