TABLE 2.
Median scores of polyuria, polydipsia, weight, appetite and serum fructosamine concentration at visit 0, visits 1–4 and visits 5–8 of dogs treated with lispro and neutral protamine Hagedorn insulins
| PU/PD scoreb | Appetite scorec | Weight scored | SFC (μmol/L) | |||||
|---|---|---|---|---|---|---|---|---|
|
Visit number a |
n | Median (range) | n | Median (range) | n | Median (range) | n | Median (range) |
| 0 | 12 | 1 (0–1) | 12 | 0 (0–1) | 12 | 0.5 (0–1) | 12 | 662 (450–990) |
| 1–4 | 44 | 1 (0–1) | 44 | 0 (0–1) | 44 | 0 (0–1) | 45 | 578 (302–996)h |
| 5–8 | 31 | 0 (0–1)e | 33 | 0 (0–1)f | 36 | 0 (0–1)g | 38 | 512 (401–974)i |
n, number of observations; PU/PD, polyuria and polydipsia; SFC, serum fructosamine concentration.
Visit 0 was the last assessment prior to commencement of the study treatment protocol. Visit 1 was the first recorded visit following 2 weeks of combined lispro and NPH insulin treatment.
bPolyuria and polydipsia were categorised as absent (0) or present (1).
cAbnormal appetite, whether increased (polyphagia) or decreased (hyporexia) received the score of 1, and normal appetite received a score of 0.
dUndesired weight change received the score of 1, while stable weight or desired weight gain received a score of 0.
eMedian PU/PD scores of combined visits 5–8 were significantly lower (improved) than median scores of combined visits 1–4 (p = 0.03) and median scores at visit 0 (p = 0.045).
fMedian appetite scores of visits 1–4 or visits 5–8 were not significantly different from the median appetite score of visit 0 (p = 0.16 and p = 0.31, respectively), nor were any significant differences found between median appetite scores of visits 5–8 compared to visits 1–4 (p = 0.41).
gMedian weight scores of visits 1–4 and visits 5–8 were insignificantly lower compared to visit 0 (p = 0.31 and p = 0.26, respectively), and no significant differences were found between median weight scores of visits 1–4 compared to visits 5–8 (p = 0.63).
hMedian serum fructosamine concentration of combined visits 1–4 was significantly lower than median serum fructosamine concentration at visit 0 (p = 0.03).
iMedian serum fructosamine concentration of combined visits 5–8 was significantly lower than median serum fructosamine concentration of combined visits 1–4 (p = 0.002) and median serum fructosamine concentration at visit 0 (p = 0.03).