Figure 2.

Summary of variants influencing the risk and protection against NAFLD and the histological disease severity. The figure depicts the most replicated variants associated with NAFLD and NASH, including the global minor allele frequency, the most severe consequence of the variant, and the linked variant functionality. In addition, the figure highlights the main effect(s) on the risk and/or protection against NAFLD and NASH. Information was retrieved from Ensembl (available at https://www.ensembl.org/). NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; PNPLA3, patatin-like phospholipase domain containing 3; HSD17B13, hydroxysteroid 17-beta dehydrogenase 13; MBOAT7, membrane bound O-acyltransferase domain containing 7; GCKR, glucokinase regulator; TM6SF2, transmembrane 6 superfamily member 2; TMC4, transmembrane channel-like 4; OR, odds ratio; MAF, minor allele frequency; SNP, single nucleotide polymorphism; LA, Latino population.