Figure 3.

Overlapping between gene variants associated with NAFLD and the immune system. This figure provides a functional enrichment analysis of the genes and proteins associated with NAFLD and the immune system, the information of which has been extracted from heterogeneous genomic and proteomic resources using the FunRich program. [55,56] The literature was searched with the query “NAFLD” and “immune system” by using the platform Genie (available at https://edoc.mdc-berlin.de/11677/) [34] with a cutoff of 0.01 for abstracts and an FDR <0.01 for genes. Pathways were ranked according to the P-value, whereby P<0.05 was considered statistically significant. % indicates the percentage of altered genes in the whole pathway. (A) Venn diagram of the corresponding gene lists with overlapping genes obtained by the FunRich program, a user-friendly tool, which performs functional enrichment analysis on the generated datasets (available at http://www.funrich.org/). [55] (B) Enrichment of genes of both lists in Biological Processes. (C) Enrichment of genes of both lists in Molecular Function. (D) Associated transcription factors. NAFLD, non-alcoholic fatty liver disease; FDR, false discovery rate.