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. 2023 Mar 21;18(3):e0283083. doi: 10.1371/journal.pone.0283083

Table 1. Sex-specific characteristics according to UACR tertile.

Korean women
Variable T1 T2 T3 p-value
Unweighted participants, n 2,325 2,324 2,332
Age, years 55.3 ± 0.22 57.6 ± 0.23 62.5 ± 0.23 <0.001
Systolic BP, mmHg 116.1 ± 0.32 119.6 ± 0.35 128.8 ± 0.35 <0.001
Antihypertensive medication, n 424 (18.2) 596 (25.6) 982 (42.1) <0.001
Diabetes, n 120 (5.2) 180 (7.7) 374 (16) <0.001
Current smoker, n 79 (3.4) 84 (3.6) 83 (3.6) 0.917
Total cholesterol, mg/dL 197.7 ± 0.74 197.1 ± 0.75 199.3 ± 0.75 <0.001
HDL-cholesterol, mg/dL 52.9 ± 0.25 52.5 ± 0.25 50.3 ± 0.25 <0.001
Urine albumin, mg/dL 0.2 ± 0 0.7 ± 0.01 4.7 ± 0.01 <0.001
Urine creatinine, mg/dL 101.6 ± 1.15 129.2 ± 1.45 115.5 ± 1.44 <0.001
UACR, mg/g 1.5 ± 0.02 5.1 ± 0.03 52.4 ± 0.03 <0.001
FRS 0.065 ± 0.001 0.079 ± 0.001 0.126 ± 0.001 <0.001
Korean men
Unweighted participants, n 1,669 1,669 1,675
Age, years 56.6 ± 0.27 57.9 ± 0.27 62.5 ± 0.27 <0.001
Systolic BP, mmHg 119.3 ± 0.36 121.8 ± 0.38 128.8 ± 0.38 <0.001
Antihypertensive medication, n 323 (19.4) 403 (24.1) 675 (40.3) <0.001
Diabetes, n 98 (5.9) 135 (8.1) 414 (24.7) <0.001
Current smoker, n 556 (33.3) 617 (37) 594 (35.5) 0.085
Total cholesterol, mg/dL 189.5 ± 0.84 190.1 ± 0.81 186.4 ± 0.81 <0.001
HDL-cholesterol, mg/dL 47.4 ± 0.28 47.3 ± 0.28 46.3 ± 0.28 <0.001
Urine albumin, mg/dL 0.2 ± 0 0.7 ± 0.01 9.9 ± 0.01 <0.001
Urine creatinine, mg/dL 142 ± 1.66 176.2 ± 1.95 155.3 ± 1.94 0.999
UACR, mg/g 1.1 ± 0.02 4 ± 0.03 80.9 ± 0.03 <0.001
FRS 0.161 ± 0.003 0.185 ± 0.003 0.272 ± 0.003 <0.001

Continuous and categorical variables are presented as mean ± standard error and number (percent), respectively. p-values for the association of continuous variables with UACR were calculated using ANOVA and those for categorical variables were calculated using the Chi-square test.

Abbreviations: UACR, urinary albumin-creatinine ratio; BP, blood pressure; HDL, high-density lipoprotein; FRS, Framingham risk score.