Fig 4. Hierarchical Bayesian calibration of tissue mechanical parameters.

(a) C₁₀, corresponding to the behavior of the non-collagenous ground substance, exhibits marked decrease between 7- and 14-days post-wounding, while mostly remaining within the broad range of values characterizing unwounded skin. (b) k₁, corresponding to the behavior of the tissue collagenous matrix, tends to decrease between 7- and 14-days post-wounding, and is typically larger in the wounds than in unwounded skin. (c) k₂, relating to the large deformation behavior of the tissue collagenous matrix, can only be inferred for unwounded skin due to the limited deformability of wounded tissues prior to failure. (d–f) Model-based predictions of the specimen tensile behavior accounting for experimental uncertainty. The dots in (a–c) indicate median values of the parameter posteriors for each of the N_s = 8 specimens, cf. S2, S3 and S4 Figs. The boxplots in (a–c) are constructed based on the values indicated by the dots, with orange lines denoting the median and extension of the whiskers denoting the 95% CI. The shadings in (d–f) indicate the 95% CI obtained from 1′000 random tensile curves generated using the calibrated Bayesian model and accounting for experimental uncertainty.