Fig 5. Results of wound healing simulations over a 21-day period using the wound mechanical parameters directly obtained from the Bayesian calibration procedure (median and 95% CI) and assuming linear variation between known or estimated values.

(a, b) Hard-coded time evolution of the mechanical parameters $C_{10}/C_{10}^{Skin}$ and $k_1/k_1^{Skin}$, along with the corresponding values from Bayesian calibration (dots, cf. Fig 4). (c) Decay of the first inflammatory signal, α, in the wound. (d–h) Time and spatial evolution of: second inflammatory signal, c; cell population, ρ; tissue collagen content, ϕ_c; tissue elastic stretch, θ^e; tissue plastic stretch, θ^p. (i) Time evolution and illustration of wound area changes. Dots and error bars in (d,e,f,i): mean ± standard deviation of previously-published experimental data, cf. S1 Appendix and Ref. [10].