Table 2.
Classification by origin, FNA site, and HPV status
| Patient | 1° tumor site | FNA site | Cobas result on cell pellet | Cobas result on cell-free supernatant | p16 IHC | HPV RNA ISH | Result (TP, TN, FP, FN) |
|---|---|---|---|---|---|---|---|
| 1 | tonsil | tonsil | HPV16 | HPV16 | Pos | TP | |
| 2 | oral cavity | oral cavity | HPV16 | HPV16 | Pos | TP | |
| 3 | tonsil | tonsil | HPV16 | HPV16 | Pos | TP | |
| 4 | tonsil | lymph node (II-IV) | HPV16 | HPV16 | Pos | TP | |
| 5 | base of tongue | lymph node (II-IV) | HPV16 | HPV16 | Pos | TP | |
| 6 | base of tongue | base of tongue | HPV16 | HPV16 | Pos | TP | |
| 7 | tonsil | tonsil | HPV16 | HPV16 | Pos | TP | |
| 8 | unknown | lymph node (neck) | Neg | Neg | Neg | TN | |
| 9 | base of tongue | base of tongue | HPV16 | HPV16 | Pos | TP | |
| 10 | base of tongue | lymph node (neck) | HPV16 | HPV16 | Pos | TP | |
| 11 | oral cavity | lymph node (neck) | Neg | Neg | Neg | TN | |
| 12 | oral cavity | lymph node (neck) | Neg | Neg | Neg | TN | |
| 13 | base of tongue | lymph node (neck) | HPVoth | HPVoth | Pos | TP | |
| 14 | oral cavity | oral cavity | Neg | Neg | Neg | TN | |
| 15 | skin | lymph node (parotid) | Neg | Neg | Neg | TN | |
| 16 | tonsil | pharynx | HPV16 | HPV16 | Pos | TP | |
| 17 | tonsil | pharynx | HPV16 | HPV16 | Pos | TP | |
| 18 | tonsil | nasopharynx | HPV16 | HPV16 | Pos | TP | |
| 19 | tonsil | nasopharynx | HPV16 | HPV16 | Pos | TP | |
| 20 | oral cavity | skin | Neg | Neg | Neg | TN | |
| 21 | oral cavity | lymph node (II-IV) | Neg | Neg | Neg | TN | |
| 22 | oral cavity | oral cavity | Neg | Neg | Neg | TN | |
| 23 | oral cavity | lymph node (II-IV) | Neg | Neg | Neg | TN | |
| 24 | base of tongue | lymph node (II-IV) | HPVoth | HPVoth | Pos | TP | |
| 25 | base of tongue | base of tongue | HPVoth | HPVoth | Pos | TP | |
| 26 | unknown | lymph node (II-IV) | HPV16 | HPV16 | Pos | TP | |
| 27 | oral cavity | oral cavity | HPV16 | Neg | Neg | Neg | FP (cells), TN (supernatant) |
| 28 | tonsil | lymph node (II-IV) | HPVoth | HPVoth | Pos | TP | |
| 29 | oral cavity | lymph node (perifacial) | Neg | Neg | Neg | TN | |
| 30 | base of tongue | lymph node (neck) | HPV16 | HPV16 | Pos | TP | |
| 31 | base of tongue | base of tongue | HPV16 | HPV16 | Pos | TP | |
| 32 | larynx | larynx | Neg | IC failure | Neg | TN (cells) | |
| 33 | oral cavity | oral cavity | Neg | Neg | Neg | TN | |
| 34 | base of tongue | base of tongue | Neg | Neg | Neg | TN | |
| 35 | skin | lymph node (parotid) | Neg | IC failure | Neg | TN (cells) | |
| 36 | oral cavity | oral cavity | Neg | Neg | Neg | TN | |
| 37 | oral cavity | lymph node (unspecified) | Neg | Neg | Neg | TN | |
| 38 | larynx | larynx | HPV16 | HPV16 | Pos | TP | |
| 39 | larynx | larynx | Neg | Neg | Neg | TN | |
| 40 | skin | lymph node (IA) | Neg | Neg | Pos | Neg | TN |
| 41 | base of tongue | base of tongue | HPV16 | HPV16 | Pos | TP |