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. Author manuscript; available in PMC: 2023 Mar 21.
Published in final edited form as: Cell. 2022 Nov 10;185(24):4560–4573.e19. doi: 10.1016/j.cell.2022.10.018

Figure 7. Model for PIP regulation of GPCR-βarr complex assembly and disassembly.

Figure 7.

GPCRs stratify into two groups with respect to the strength of their interaction with βarrs: one group requires an interaction between βarrs and PIPs at the PM for recruitment (PIP required, left), whereas the other does not (PIP not required, right).