Table 4.

Effects of patient characteristics and targeted therapy on baseline DAS28 and on annual rate of changes in DAS28 prevaccination and post vaccination in patients with RA

	Effects on baseline DAS28 (points)		Effects on annual rate of change in DAS28 (points/year)
		P value	Prevaccination	P value	Post vaccination	P value
Intercept	2.600±0.211	<0.001	−0.038±0.042	0.366	−0.871±1.019	0.393
Gender (ref. woman)	−0.361±0.099	<0.001	−0.026±0.019	0.172	0.939±0.464	0.043
Age at vaccination (per year)	0.010±0.003	0.004	0.001±0.001	0.252	0.004±0.016	0.800
Targeted therapy at vaccination (ref. TNF-i)	−0.066±0.068	0.332	−0.052±0.015	<0.001	0.581±0.372	0.118

Plus-minus values represent means±SE.

DAS28, Disease Activity Score in 28 joints; RA, rheumatoid arthritis; ref., reference; TNF-i, tumour necrosis factor inhibitor.