Skip to main content
. 2022 Dec 26;62(3):1357–1375. doi: 10.1007/s00394-022-03074-9

Table 3.

Significant results of the meta-analyzed EWAS of KORA FF4, TwinsUK and Leiden Longevity Study

ProbeID Studies* Effect- size** p value FDR p value Q-statistic I2*** Foodgroup Chr RefGene name RefGene group Relation to CpG Island
cg06618277 K–L–T − 1.39e-04 0.050 0.215 0.349 [0.000;0.789] Onions-garlic 13 N/A N/A N/A
cg13970894 K–L–T − 4.16e-04 0.050 0.706 0.000 [0.000;0.702] Onions-garlic 10 N/A N/A N_Shore
cg03046445 K–L–T 9.94e-05 0.019 0.012 0.774 [0.266;0.930] Nuts-seeds 12 BHLHE41* 1stExon* N_Shore
cg05275153 K–L–T − 4.39e-05 4.96e-05 3.14e-06 0.921 [0.801;0.969] Nuts-seeds 4 RGS12* Body* N/A
cg08633290 K–L–T − 6.72e-04 1.70e-05 2.79e-05 0.905 [0.748;0.964] Nuts-seeds 19 N/A N/A N_Shore
cg09418283 K–L–T 7.31e-05 0.005 0.013 0.770 [0.252;0.929] Nuts-seeds 12 PAWR* 1stExon* Island
cg10530560 K–L–T − 1.40e-04 6.49e-07 0.027 0.722 [0.060;0.918] Nuts-seeds 12 GLI1* 5'UTR* S_Shelf
cg11701148 K–L–T 2.64e-04 0.005 0.134 0.503 [0.000;0.856] Nuts-seeds 8 MYOM2 TSS200 N/A
cg12430457 K–L–T − 2.00e-04 0.047 4.47e-04 0.870 [0.630;0.955] Nuts-seeds 12 SYT1* 5'UTR* N/A
cg12611195 K–L–T − 1.22e-04 0.038 9.64e-11 0.957 [0.905;0.980] Nuts-seeds 6 PPP1R14C Body N/A
cg13471114 K–L–T 2.21e-04 0.036 0.190 0.397 [0.000;0.814] Nuts-seeds 2 OTX1 TSS1500 Island
cg14436861 K–L–T − 2.70e-04 4.96e-05 2.89e-07 0.934 [0.840;0.972] Nuts-seeds 11 WEE1* 3'UTR* N/A
cg14828673 K–L–T − 1.17e-04 0.027 0.022 0.739 [0.126;0.922] Nuts-seeds 8 TOP1MT Body N/A
cg15864779 K–L–T − 2.77e-05 0.005 0.995 0.000 [0.000;0.000] Nuts-seeds 17 ATP5H* TSS200* Island
cg16790682 K–L–T 8.13e-05 0.038 0.007 0.798 [0.360;0.936] Nuts-seeds 12 PIP4K2C* TSS200* Island
cg21251785 K–L–T − 3.12e-04 0.020 2.08e-10 0.955 [0.901;0.980] Nuts-seeds 9 TRPM3* TSS1500* N/A
cg23415756 K–L–T 5.25e-05 0.001 0.273 0.229 [0.000;0.920] Nuts-seeds 17 NTN1 Body Island
cg25554998 K–L–T − 2.43e-04 0.027 0.005 0.811 [0.411;0.940] Nuts-seeds 11 N/A N/A N_Shore
cg27344289 K–L–T − 2.49e-04 1.19e-04 0.002 0.834 [0.497;0.945] Nuts-seeds 5 FLJ41603 Body N/A
cg27496650 K–L–T 5.30e-05 0.008 0.363 0.012 [0.000;0.897] Nuts-seeds 8 TOX TSS1500 Island
cg14732699 K–T 5.60e-06 0.049 0.140 0.540 [0.000;0.887] Milk 8 MYC Body Island
cg03846926 K–L–T 2.26e-04 0.048 0.007 0.799 [0.363;0.936] Cream 10 C10orf140 5'UTR S_Shore
cg06947913 K–L–T 2.82e-04 0.020 3.95e-14 0.968 [0.934;0.984] Cream 12 FAIM2 TSS200 Island
cg08846079 K–L–T − 4.73e-04 0.044 0.518 0.000 [0.000;0.842] Cream 1 N/A N/A N/A
cg09398214 K–L–T 1.21e-04 0.038 5.70e-08 0.940 [0.859;0.975] Cream 17 MARCH10* Body* Island
cg10156125 K–L–T 3.86e-04 0.020 5.53e-11 0.958 [0.908;0.981] Cream 4 UGT8* 5'UTR* Island
cg13331940 K–L–T 1.82e-04 0.036 7.79e-16 0.971 [0.943;0.986] Cream 15 MYO1E Body Island
cg13923646 K–L–T − 3.30e-04 0.048 0.234 0.311 [0.000;0.928] Cream 1 N/A N/A N/A
cg17353893 K–L–T − 2.15e-04 0.020 2.07e-31 0.986 [0.975;0.992] Cream 7 CLIP2* Body* Island
cg22028181 K–L–T 1.31e-04 0.026 7.67e-21 0.978 [0.959;0.989] Cream 15 CYFIP1 TSS200 Island
cg25734572 K–L–T 1.46e-04 0.036 9.21e-05 0.892 [0.707;0.960] Cream 19 N/A N/A Island
cg26633077 K–L–T − 6.99e-04 0.048 5.44e-28 0.984 [0.972;0.991] Cream 17 RPTOR* Body* S_Shelf
cg02488288 K–L 3.29e-04 0.044 0.006 0.868 [0.481;0.967] Plant-oils 5 SPRY4* TSS1500* N_Shore
cg03995571 K–L 7.05e-05 0.010 0.015 0.833 [0.303;0.960] Plant-oils 8 FAM49B TSS1500 Island
cg11189177 K–L − 4.92e-04 0.044 3.95e-04 0.920 [0.726;0.977] Plant-oils 17 ABR* Body* S_Shore
cg18419070 K–L − 4.78e-04 0.028 0.018 0.820 [0.239;0.957] Plant-oils 3 SEMA5B Body N/A
cg02924347 K–L–T 6.31e-05 0.049 0.875 0.000 [0.000;0.220] Butter 16 ABCA17P* TSS1500* Island
cg05781609 K–L–T − 2.57e-04 0.020 2.48e-14 0.968 [0.935;0.984] Butter 1 COL24A1 Body N/A
cg07410571 K–L–T 5.11e-05 0.049 0.718 0.000 [0.000;0.685] Butter 20 DDRGK1 TSS200 Island
cg11798857 K-L–T 7.20e-04 0.034 0.693 0.000 [0.000;0.716] Butter 20 FOXA2* TSS1500* N_Shore
cg11934386 K–L–T 4.75e-05 2.49e-04 5.55e-10 0.953 [0.896;0.979] Butter 7 C7orf41* 1stExon* Island
cg13934553 K–L–T − 3.64e-05 0.020 5.21e-04 0.868 [0.621;0.954] Butter 1 PLEKHG5* Body* Island
cg14046757 K–L–T 5.29e-05 1.63e-04 1.65e-20 0.978 [0.959;0.988] Butter 14 ZC3H14* TSS200* Island
cg14981983 K–L–T 3.95e-05 0.034 1.03e-12 0.964 [0.924;0.983] Butter 19 ZNF527 TSS200 Island
cg18247124 K–L–T − 2.85e-04 5.45e-04 5.87e-12 0.961 [0.918;0.982] Butter 11 ASAM 3'UTR N/A
cg19200140 K–L–T − 4.27e-04 0.049 0.188 0.402 [0.000;0.816] Butter 20 N/A N/A N_Shelf
cg19526600 K–L–T 1.70e-04 0.034 0.825 0.000 [0.000;0.461] Butter 1 DIO1* 1stExon* N/A
cg26351764 K–L–T 6.36e-05 0.024 1.03e-12 0.964 [0.924;0.983] Butter 20 FAM83D TSS200 Island
cg26502414 K–L–T 4.70e-05 0.025 0.798 0.000 [0.000;0.538] Butter 17 METT10D 5'UTR N_Shore

UCSC RefGene Name Target gene names from the UCSC database, UCSC RefGene Group Describing CpG position. TSS1500 = 200–1500 bases upstream of the Transcription start site (TSS), 5-UTR Within the 5' untranslated region, between the TSS and the ATG start site; Body = Between the ATG and stop codon, irrespective of the presence of introns, exons, TSS or promoters, 3'UTR Between the stop codon and the poly A signal, Relation to UCSC CpG Island The location of the CpG relative to the CpG Island. Shore = 0–2 kb from Island; Shelf = 2–4 kb from Island, N Upstream (5') of CpG Island, S Downstream (3') of CpG Island [66]

*K is short for KORA FF4 inclusion; L is short for Leiden longevity study inclusion; T is short for TwinsUK inclusion

**Effect sizes are %-methylation change per g/day residual intake

***I2 is reported with 95%-confidence interval in brackets as calculated by the metagen function of the meta package

*After a gene name indicates available splice variants