Table 3.
Characteristics of 21 CRKP clinical isolates carrying CRISPR-Cas systems.
| Isolate | CRISPR type | Carbapenemase | Extended-spectrum β-lactamase | blaKPC-2-carrying plasmid size (Kb) | blaKPC-2-carrying plasmid type | ST | MIC (μg/mL) | ||
|---|---|---|---|---|---|---|---|---|---|
| ETP | IPM | MEM | |||||||
| HSKP5 | Type I-E* | KPC-2 | CTX-M-15, SHV-106, SHV-28 | 94.1 | IncFIIK34 | 15 | >32 | 32 | 64 |
| HSKP8 | Type I-E* | KPC-2 | CTX-M-15, SHV-106, SHV-28 | 94.4 | IncFIIK34 | 15 | 32 | 8 | 4 |
| HSKP33 | Type I-E* | KPC-2 | CTX-M-3, SHV-106, SHV-28 | 120.5 | IncFIIK34 | 15 | >32 | 64 | 128 |
| HSKP43 | Type I-E* | KPC-2 | CTX-M-15, SHV-106, SHV-28 | 94.1 | IncFIIK34 | 15 | >32 | 64 | 128 |
| HSKP86 | Type I-E* | KPC-2 | CTX-M-15, SHV-106, SHV-28 | 94.1 | IncFIIK34 | 15 | >32 | 32 | 128 |
| HSKP104 | Type I-E* | KPC-2 | CTX-M-15, SHV-106, SHV-28 | 94.1 | IncFIIK34 | 15 | >32 | 32 | 64 |
| HSKP107 | Type I-E* | KPC-2 | CTX-M-15, SHV-106, SHV-28 | 94.1 | IncFIIK34 | 15 | >32 | 32 | 64 |
| RJKP14 | Type I-E* | KPC-2 | SHV-106, SHV-28 | 108.8 | IncFIIK34 | 15 | >32 | 128 | 64 |
| HSKP39 | Type I-E* | KPC-2 | SHV-12, SHV-13, SHV-31, SHV-129 | 114.7 | IncFIIK34 | 23 | >32 | 16 | >128 |
| HSKP1 | Type I-E* | KPC-2 | SHV-106, SHV-28 | 142.1 | IncFII(PHN7A8) | 15 | >32 | 128 | 128 |
| RJKP41 | Type I-E* | KPC-2 | CTX-M-65, SHV-106, SHV-28 | 164.6 | IncFII(PHN7A8) | 15 | >32 | 128 | 64 |
| GZKP13 | Type I-E* | KPC-2 | CTX-M-14, SHV-106, SHV-28 | 56.2 | IncFIA(HI1) | 15 | >32 | 32 | 64 |
| RJKP36 | Type I-E* | KPC-2 | CTX-M-15, SHV-106, SHV-28 | 108.8 | IncR | 15 | 16 | 16 | 8 |
| HSKP69 | Type I-E | – | SHV-26, SHV-78, SHV-98, SHV-145 | – | – | 45 | >32 | 64 | >128 |
| HSKP40 | Type I-E | – | SHV-5, SHV-2, SHV-102 | – | – | UT | >32 | 8 | >128 |
| GSKP2 | Type I-E* | – | CTX-M-14, SHV-33 | – | – | 449 | 32 | 0.25 | 0.06 |
| SCKP43 | Type I-E* | – | CTX-M-55, SHV-106, SHV-28 | – | – | 15 | 16 | 1 | 0.5 |
| ZJKP62 | Type I-E* | – | SHV-75 | – | – | 420 | 16 | 0.25 | 0.5 |
| HSKP140 | Type I-E | – | CTX-M-3, SHV-110, SHV-191 | – | – | 2,485 | 8 | 0.25 | 1 |
| HSKP155 | Type I-E | – | SHV-27 | – | – | 3,393 | 8 | 0.5 | 0.25 |
| ZJKP12 | Type I-E* | – | SHV-106, SHV-28 | – | – | 14 | 4 | 0.5 | 1 |
ETP, ertapenem; IPM, imipenem; MEM, meropenem; MIC, minimum inhibitory concentration; ST, sequence type.