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CVS+ and CVS− distribution according to age groups and brain subregions. In all age groups and brain subregions, CVS+ lesion number is higher than CVS− lesions (**p < 0.001; *p = 0.033), except for the juxtacortical area in age Group 4 where the difference is not significant. Note that in the deep/subcortical WM in age Group 4 (57–77 years) CVS− lesion number rises and becomes higher than CVS+ lesions, although not statistically significant. CVS, Central Vein Sign.
