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. 2023 Mar 8;14:1140749. doi: 10.3389/fimmu.2023.1140749

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Copyright © 2023 Wu, Yan, Jiang, Chen, Du, Guo, Xu, Luo and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of glycolysis on DC activation and pro-inflammatory activity. (A) Quiescent DCs recognize pathogen-associated molecular patterns (PAMPs) that are required for DC maturation, along with a rapid increase in glycolysis. (B) Increased glycolysis increases DC activation and antigen presentation after TLR activation. (C) Glycolysis also promotes the migration of activated DCs by stimulating CCR7 oligomerization. (D) Activated DCs in lymph nodes express co-stimulatory markers, initiating T-cell priming Biorender.com.