TABLE 1.

Treatment in cancer.

Targets	Drugs	Cancer types	Mechanisms
SREBP1/SREBP2	Fatostatin	Prostate cancer	Inhibits cell proliferation, invasion, and migration of cancer cells and causes G2-M cell cycle arrest and induces apoptosis (Li et al., 2014b)
			Inhibits prostate tumor growth and distant lymph node metastasis in mice by inhibiting the activation of SREBPs (Chen et al., 2018)
			Combined use with docetaxel can inhibit the proliferation and apoptosis of prostate cancer cells (especially p53 mutants) to a greater extent (Li et al., 2015d)
		Endometrial cancer	Inhibits metabolic signaling pathways regulated by SREBPs and induces caspase-mediated apoptosis (Gao et al., 2018)
			Inhibits growth, proliferation, cell cycle, and apoptosis and has antitumor activity in vivo (Yao et al., 2020)
		Breast cancer	Causes cell cycle arrest and apoptosis by ER stress (Brovkovych et al., 2018)
		Multiple cancers	Inhibits tubulin polymerization and mitosis and perturbs its mitotic microtubule spindle assembly (Gholkar et al., 2016)
	Betulin	Hepatocellular carcinoma	Reduces the levels of pro-inflammatory lipids and suppresses inflammation and ER stress by inhibiting the translocation of SREBPs (Li et al., 2017)
			Inhibits glucose metabolism and enhances the antitumor effect of Sorafenib by inhibiting SREBP1 (Yin et al., 2019)
	PF-429242	Renal cell carcinoma	Inhibits cell proliferation, migration, and invasion, and activates apoptosis by targeting S1P (Wang et al., 2021b)
		Hepatocellular carcinoma	Inhibits viral assembly in infected cells by reducing LD formation, thereby blocking HCV establishment of infection (Blanchet et al., 2012; Olmstead et al., 2012)
			Synergizes with GSK343, enhancing the anticancer activity of GSK343 (Yang et al., 2019)
		Glioblastoma	Downregulates steroid, isoprenoid, and unsaturated fatty acid biosynthetic signaling pathways and upregulates pro-inflammatory genes to reduce cancer cell viability and promote apoptosis (Caruana et al., 2017)
	Nelfinavir,1,10-phenanthroline	Liposarcoma	Upregulates the precursors SREBP1 and ATF6 by inhibiting the cleavage of S2P, resulting in ER stress and induction of apoptosis (Guan et al., 2011)
		Prostate cancer	Reduces the proliferation of castration-resistant prostate cancer and promotes apoptosis through the accumulation of unprocessed SREBP1 and ATF6 (Guan et al., 2012; Guan et al., 2015)