TABLE 2.

Treatment in cancer.

Targets	Drugs	Cancer types	Mechanisms
SREBP1	Apatinib	Gastric cancer	Downregulates GPX4 expression by inhibiting SREBP1a, thereby inducing lipid peroxidation and ferroptosis (Zhao et al., 2021)
	Mollugin	Breast/ovarian cancers	Inhibits proliferation and induces apoptosis through the HER2/Akt/SREBP1c/FASN signaling pathway (Do et al., 2013a)
	WY 14,643 and troglitazone	Hepatocellular carcinoma	inhibit SREBP1 activation through the upregulation of INSIG, ultimately reducing triacylglycerol synthesis (König et al., 2009)
	Azathioprine	Glioblastoma	Inhibits elevated lipid metabolism via EGFR/AKT/SREBP1 signaling pathway and induces ER stress to induce apoptosis (Nam et al., 2021)
	GW3965	Glioblastoma	Promotes cell death by inhibiting the EGFR/AKT/SREBP1/LDLR signaling pathway (Guo et al., 2011)
	Gefitinib	Non-small cell lung cancer	Induces downregulation of SREBP1, and alters the ratio of saturated to unsaturated phospholipids (Xu et al., 2021a)
	Metformin	Bladder cancer	Inhibits cancer cell growth by controlling lipid synthesis via the Clusterin/SREBP1c/FASN axis (Deng et al., 2021)
	Proxalutamide	Prostate cancer	Inhibits proliferation, migration, and expression of ACL, ACC, FASN, and SREBP1 to reduce lipid droplet levels and triglyceride content (Gu et al., 2021)
	ASC-J9	Prostate cancer	Inhibits the proliferation and invasion of prostate cancer cells by the AR/SREBP1/FASN or API3K/Akt/SREBP1/FASN signaling pathways according to whether AR is positive or not (Wen et al., 2016)
	RA-XII	Colorectal cancer	Inhibits the growth and metastasis of colorectal tumors by reducing the expression of SREBP1 and its target genes (Wang et al., 2019)
	Berberin	Colon cancer	Mediates lipogenesis by inhibiting SCAP expression and SREBP1 activation, thereby inhibiting cell proliferation and colon cancer xenograft growth (Liu et al., 2020)
	Ginsenoside Rh2	Non-small cell lung cancer	Reverses cyclophosphamide-induced immunodeficiency by inhibiting the expression of SREBP1 and affecting the interaction of SREBP1 with FASN (Qian et al., 2019)
	Davallia formosana ethanol extract	Prostate cancer	Inhibits proliferation, migration, and invasion by inhibiting the expression of SREBP1 and FASN and reducing the expression of AR and PSA (Hsieh et al., 2020)
	Curcumin	Hepatocarcinoma	Reduces adipogenesis by activating the phosphorylation of AMPK to reduce the expression of SREBP1 and FASN and increases the expression of PPARα (Kang et al., 2013)
	Oleiferasaponin A₂	Hepatocarcinoma	Inhibits lipid accumulation by significantly down-regulating fatty acid synthesis genes and up-regulating fatty acid β-oxidation genes (Di et al., 2018)
	Piperine	Breast cancer	Reduces the expression of SREBP1 and FASN by inhibiting ERK1/2 signaling, and also inhibits the proliferation by activating caspase-3 and cleaving PARP (Do et al., 2013b)