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. 2023 Mar 21;14:1558. doi: 10.1038/s41467-023-37173-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — We obtained CMR-derived LVM index in 44,375 individuals undergoing CMR imaging. We performed a genome-wide association study of CMR-derived LVMI and assessed for associations between CMR-derived LVMI and cardiovascular outcomes. Using GWAS results, we developed a polygenic risk score for LVMI, and applied it to 443,326 separate UK Biobank participants with genetic data (left), and 29,354 individuals from the independent Mass General Brigham Biobank (right), to assess for associations between genetically determined LVMI and cardiovascular outcomes.