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. 2023 Mar 21;14:1558. doi: 10.1038/s41467-023-37173-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Depicted are plots showing the relative hazard of incident implantable cardioverter-defibrillator (ICD) implant as a function of increasing standardized CMR-derived LVM index (left), increasing standardized LVMI PRS in UK Biobank (middle) and increasing standardized LVMI PRS in Mass General Brigham (MGB, right). In each plot, the y-axis depicts the relative hazard of incident ICD compared to the hazard observed for individuals with an average LVMI (left) or average PRS value (middle and right), derived from Cox proportional hazards models adjusted for age and sex (left), and adjusted for age, sex, and the first five principal components of genetic ancestry (middle and right). The relative hazard is plotted on the logarithmic scale. The functional form of the association was selected empirically using a penalized spline approach, in which the degrees of freedom for the penalized spline fit were chosen based on minimization of the corrected Akaike Information Criterion⁷⁵. The number of events and individuals included in each analysis are listed above each plot.