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. 2023 Mar 16;11(3):e005301. doi: 10.1136/jitc-2022-005301

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Multiplexed immunofluorescence analysis of OX40 expression. (A) OX40 expression in baseline tumor biopsies (fresh and archival samples). Baseline tumor expression of OX40 is low (0% to 1.4% across all tested samples). (B) Dose dependence of fold changes in OX40+ cell subsets from baseline to on-treatment (week 6) paired fresh tumor biopsies. From left to right: Row 1: CD134+, PD-1+CD134+; Row 2: CD16−CD56+CD134+, CD16+CD56−CD134+, CD16+CD56+CD134+; Row 3: CD3+CD4+ FOXP3−CD134+, CD3+CD4+FOXP3+CD134+, CD3+CD4+FOXP3+PD-1+CD134+, CD3+CD4+FOXP3−PD-1+CD134+; Row 4: CD3+CD8+granzyme B−CD134+, CD3+CD8+granzymeB+CD134+, CD3+CD8+granzymeB−PD-1+CD134+, CD3+CD8+granzymeB+PD-1+CD134+. CD, cluster of differentiation; FOXP3, forkhead box protein 3; PD-1, programmed cell death 1 protein.