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. 2022 Sep 16;17(1):55–74. doi: 10.1007/s12079-022-00695-x

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Fig. 1 — The IL-6/IL-6R axis. Dimerization of gp130, IL-6R, and IL-6 is essential for the initiation of signal transduction and activation of various pathways such as NFKB and STAT3. IL-6R can be in two forms; mIL-6R and sIL-6R. The soluble form of IL-6R is created by mRNA splicing as well as the proteolytic cleavage of the mIL-6R by ADAM10 or ADAM17. STAT; signal transducer and activator of transcription, NFKB; nuclear factor-kappa B, ADAM; A disintegrin and metalloprotease, sIL-6R; soluble IL-6R, mIL-6R; membrane IL-6R