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. 2023 Mar 21;14(3):205. doi: 10.1038/s41419-023-05716-0

Fig. 2. Ferroptosis is a type of autophagy-dependent cell death.

Fig. 2

NCOA4-mediated ferritinophagy induces ferritin degradation and iron overload, finally promoting oxidative injury and ferroptosis. E3 ubiquitin ligase HERC2 drives the proteasomal degradation of NCOA4 and enhances the stabilization of ferritin, which decreases intracellular levels of iron. RAB7A-mediated lipophagy and SQSTM1-mediated clockophagy both contributes to lipid peroxidation in ferroptosis. Erastin not only increases the expression of Lamp-2a, which promotes HSP90-mediated chaperone-mediated autophagy to degrade GPX4, but also promotes the combination of BECN1 and SLC7A11 to block System Xc- activity via AMPK phosphorylation.