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. 2023 Mar 21;13:4630. doi: 10.1038/s41598-023-31811-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Explored strategies for loading TMZ in chitosan-based thermogels. (a) For SiO₂-TMZ, the drug is adsorbed on mesoporous silica (SiO₂) via electrostatic interactions, and the colloid is then dispersed in the thermogel matrix. For PCL-TMZ, the drug is dissolved together with PCL in a dichloromethane/methanol (DCM/MeOH) mixture and spray-dried to afford PCL-TMZ microparticles that physically entrapped the drug. The drug-loaded microparticles were then formulated in the chitosan/βGP thermogel (THG). (b) Scanning electron micrographs of freeze-dried THG@PCL-TMZ. (c) THG@PCL-SiO₂-TMZ. TMZ-loaded microcarriers are highlighted with dashed circles.