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The effects of repeat element orientation. A. L1 shows an integration preference for the template strand and leading strand orientations. B. Polyadenylation signals within L1 repeats in introns in the template orientation can result in premature termination of transcription. C. Antisense promoters in L1 repeats can drive transcription of nearby genes. D. Two Alu repeats in opposite orientations can form hairpin structures (Created with BioRender.com).
