Table 2.
Description of Zebrafish endpoints that are available on the portal as defined in Thomas et al.37 and ontology identifiers where available.
| Endpoint labels | Short Name | Description | Ontology ID |
|---|---|---|---|
| MO24 | Mortality at 24 hours | Death occurred shortly after chemical dosing to 24 hpf. | ZP:0000306 |
| CRAN | Craniofacial | Periocular edema, abnormally small or missing eye(s), misshapen snout and protruding jaw form a highly correlated suite of malformations simplified to ‘craniofacial defects.’ | ZP:0000943; ZP:0007203 |
| AXIS | Axis | The body axis is visibly curved, either concave or convex, where control animals are straight. | ZP:0005012 |
| EDEM | Edema | Distended clear region around the heart and/or yolk sac or top of the head with a lumpy appearance of swollen tissue. | ZP:0002060 |
| LTRK | Lower Trunk | Shorter than normal body from the posterior of the yolk sac to the caudal fin, abnormal caudal fin | ZP:0003437; ZP:0010405 |
| BRN | Brain | Brain region abnormal in appearance based on color or size. | ZP:0001601; ZP:0000100; ZP:0008625 |
| ANY_MORT | Any effect except mortality | Any morphological abnormality not including mortality | |
| ANY120 | Any effect in 5 days | Any abnormality or death within 5 days (combination of all measurements at 24 hr and 5 days) | |
| ANY24 | Any effect in 24 hours | Any abnormality or death at 24hrs (aggregation of MO24, DP24, SM24 and NC24) | |
| TOT_MORT | Total Mortality | Total mortality (aggregation of MO24 and MORT) | |
| AUC1 | 5 day total movement | Behavior-total movement in dark minus total movement in light for the first light/dark cycle | ZP:0012599 |
| MOV1 | 5 day behavior transition | Behavior-transition from light to dark for the first light/dark cycle | ZP:0012599 |
Some end points summarize a combination of other endpoints.