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. 2023 Mar 8;14:1145737. doi: 10.3389/fneur.2023.1145737

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Copyright © 2023 Herrera-Rivero, Hofer, Maceski, Leppert, Benkert, Kuhle, Schmidt, Khalil, Wiendl, Stoll and Berger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic associations with serum neurofilament light chain were only identified at the suggestive level. Manhattan and quantile-quantile (QQ) plots for the discovery genome-wide association study in BiDirect (N = 1,899) (A), and its meta-analysis with ASPS-Fam (N = 2,186) (B). Yellow lines in the Manhattan plots mark the suggestive threshold for genome-wide significance (p < 1 × 10⁻⁵).