Fig. 4. The LncRNA PVT1 knockdown inhibits xenograft tumor growth and enhances apoptosis in nude mice.

A, B Tumor engraftment sizes in nude mice injected with sh-NC or sh-PVT1#3 A431 cells on the right subcutaneous axilla (1 × 10⁷ cells/ml). C Tumor volume (mm³) was assessed every 3 days. D Quantitation of weight of tumors dissected from xenograft tumor models. E LncRNA PVT1 expression in xenograft tumor tissues measured by RT-qPCR. F CSCC histology by HE staining and Ki-67 and TUNEL measured by immunohistochemistry (×200 magnification, scale bar = 50 µm). *P < 0.05, **P < 0.01.