Fig. 2.

Polyneuro risk score framework methodology. An in-depth overview of each step within the polyneuro risk score framework. (A) Behavioral measures and functional connectivity from ARMS-1 subjects are used to calculate the weighted contribution, beta-weights, of each connection. (B) Beta-weights can be evaluated by explained variance achieved at three distinct levels: single connection, connections within a network pair, and a percentage of the top connections, when ranked by their p-values. The method by which beta-weights are evaluated dictates which connections are used to generate the PNRS. (C) Estimated beta-weights from (A) are then applied to the functional connectivity data from ARMS-2 subjects to calculate a PNRS. The PNRS can then be compared to the independent behavioral scores for ARMS-2 subjects.