Table 3.
Results of subgroup analyses (A) and quantitative variable analyses (B) – temporal effects on choroid plexus.
| Variable | Subgroup | Estimate | Std. Error | p-value | 95% CI |
|---|---|---|---|---|---|
| (A) | |||||
| Sex | Female* | 20.43 | 2.81 | <0.001 | (14.91, 25.93) |
| Male* | 9.48 | 2.75 | <0.001 | (4.08, 14.87) | |
| Dg. Group | CN | 10.07 | 2.7 | <0.001 | (4.77, 15.36) |
| MCI | 14.5 | 2.93 | <0.001 | (8.75, 20.23) | |
| AD | 20.41 | 13.38 | 0.129 | (−6.09, 46.52) | |
| Convertor* | 24.88 | 5.56 | <0.001 | (14, 35.82) | |
| ApoE | ApoE E4 non-carrier | 12.52 | 2.29 | <0.001 | (8.02, 17.02) |
| ApoE E4 heterozygote | 12.12 | 3.75 | 0.001 | (4.75, 19.45) | |
| ApoE E4 homozygote* | 40.72 | 7.51 | <0.001 | (25.97, 55.46) | |
| Hypertension | No | 15.87 | 2.58 | <0.001 | (10.8, 20.93) |
| Yes | 13.57 | 3.03 | <0.001 | (7.62, 19.49) | |
| (B) | |||||
| Age* | −0.6 | 0.27 | 0.027 | (−1.14, −0.07) | |
| Education | −1.14 | 0.75 | 0.131 | (−2.61, 0.34) | |
| BMI | −0.7 | 0.4 | 0.078 | (−1.49, 0.08) | |
| GDS* | 2.79 | 1.33 | 0.036 | (0.18, 5.4) | |
Annual change in choroid plexus volume in specified subgroup/for one unit of quantitative variable. Temporal effects (as obtained by time × variable interaction) only. Baseline corrected for age, and for sex, diagnostic group and ApoE as appropriate. Asterisk (*) denotes significance for the group difference (time × variable interaction on pooled data). All quantitative variables (Table 3B) considered as baseline values only. Sex coded as 0 = males, 1 = females. For multi-level variables Dg. group and ApoE, the comparison variable is CN and ApoE E4 non-carrier, respectively. Rounding for 2 decimal places (3 for p-value). CI, confidence interval; AD, Alzheimer’s disease dementia; MCI, mild cognitive impairment; BMI, body mass index; GDS, geriatric depression scale.