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Biocompatibility test of nanoparticles in vitro and in vivo. (A) Toxicity test of liposome/mRNA complexes in DC2.4 cells. (B,C) Liver function assay of mice with different treatments. (D–F) Renal function assay of mice with different treatments. Data are presented as mean ± SD (n = 3). ∗P < 0.005. ∗∗∗P < 0.001. (G) H&E staining of heart, liver, spleen, lung and kidney pathology 10 days after the initial immunization (scale bar = 200 μm).
