Figure 5.

Rudimentary anti-epileptic efficacy study of micelles in vivo. (A) Treatment schedule; Epileptic rats were administered with different preparations on Days 1, 3, 6 and 10 after modeling; One day after each administration, rats were sacrificed to prepare samples for further analysis; (B) Weight of rats was recorded synchronously during the medication (before modeling and on Days 1,3, 6, 8, 10 and 12). Data are presented as mean ± SD (n = 20, 15, 10 or five at different time points); (C) The movement track of rats captured by Morris water maze camera for 1 min per group in open-field tests (Day 10); (D) Quantification of motion distance automatically calculated by Morris water maze software in open-field tests (Day 10). Results are presented as mean ± SD (n = 3, ∗P < 0.05, ∗∗∗∗P < 0.0001); (E) Nissl's staining of neurons' morphologic changes in rat hippocampus (scale bar: 200 μm for thumbnails and 20 μm for large images; mottled blue signal: Nissl's bodies; Day 10).