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. 2022 Sep 30;13(3):1246–1261. doi: 10.1016/j.apsb.2022.09.019

Figure 6.

Figure 6

Advanced anti-epileptic efficacy study of micelles in vivo. (A) Illustration of epileptic inflammatory microenvironment and the therapeutic mechanism of the nano-medicine; (B) Immunofluorescence staining of reactive gliosis in rat hippocampus (scale bar: 100 μm; blue signal: DAPI; green signal: Iba-1; red signal: GFAP; Day 10); (C) Measurement of pro-inflammatory cytokines (NF-κB pp65 and HMGB1) in rat hippocampus and cortex (Day 10) by western blot (β-actin served as the inner parameter); (D) Measurement of pro-inflammatory cytokines (IL-1β and TNF-α) in rat hippocampus and cortex (Day 10) by enzyme-linked immunosorbent assay (ELISA). Results are presented as mean ± SD (n = 3, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001).