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. 2022 Nov 15;13(3):1036–1052. doi: 10.1016/j.apsb.2022.11.012

Figure 2.

Figure 2

CDDP treatment improves HFD-induced cardiac dysfunctions in ApoE–/–LDLR–/– mice. (A) The ratio of heart weight to bodyweight (n = 5). (B, C) HE staining of mouse heart cross sections with quantitation of the cross-sectional area. (D–H) Levels of serum CK, LDH, BNP, HBDH and NT-proBNP were determined by assay kits (n = 5–8). (I) Expression of Anf, Bnp and β-Mhc mRNA was determined by qRT-PCR (n = 5). (J) HE staining of mouse heart section to determine infiltration of inflammatory cells. (K, L) Picrosirius red staining and Masson trichrome staining of heart sections. (M) mRNA levels of Col1a1, α-Sma and Tgf-β were determined by qRT-PCR (n = 5). The data are shown as mean ± SEM. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001; #P < 0.05, ###P < 0.001; ns: not significantly different between indicated groups. ANF, atrial natriuretic factor; CK, creatine kinase; α-Sma, alpha smooth muscle actin; Col1a1, collagen type I alpha 1 chain; HDBH, α-hydroxybutyrate dehydrogenase; LDH, lactate dehydrogenase; NT-proBNP, N-terminal pro-brain natriuretic peptide.