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. 2022 Nov 15;13(3):1036–1052. doi: 10.1016/j.apsb.2022.11.012

Figure 6.

Figure 6

CDDP blocks HFD-induced hepatic lipid accumulation and simvastatin-induced myolysis in skeletal muscle. Serum and tissue samples of mice in Fig. 1 were conducted the following assays. Determination of hepatic lipid levels by oil red O staining of liver frozen sections (A) and TG quantitative assay (B). Levels of serum TG (C), CHO, LDL-C and HDL-C (D). The data are shown as mean ± SEM. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001; ns: not significantly different between indicated gruops. Expression of FASN, SCD1, DGAT, HSL, ATGL (E), ABCG5 and CYP7A1 (F) protein in the liver was determined by Western blot. (G) HE staining of mouse skeletal muscle sections. ATGL, adipose triglyceride lipase; CHO, cholesterol; DGAT, diacylglycerol O-acyltransferase; FASN, fatty acid synthase; HDL-C, high-density lipoprotein cholesterol; HSL, hormone sensitive lipase; LDL-C, low-density lipoprotein cholesterol; SCD1, stearoyl CoA desaturase 1.