Table 2.

Random effect regression models over 24 weeks. Model 0 unadjusted, and model 1 adjusted for age, sex, and disease duration (n=59; observations=177).

Assessment			Model 0					Model 1
			r (SE)		P value		r (SE)			P value
DLQIa
	Week 0	Refb		Ref		Ref			Ref
	Week 12	–0.561 (0.205)		.006		–0.561 (0.205)			.006
	Week 24	–0.855 (0.205)		<.001		–0.855 (0.205)			<.001
	Intervention group	Ref		Ref		Ref			Ref
	Control group	–0.234 (0.288)		.42		–0.128 (0.288)			.66
	Week 0 × control	Ref		Ref		Ref			Ref
	Week 12 × control	0.450 (0.262)		.09		0.450 (0.262)			.09
	Week 24 × control	0.420 (0.262)		.11		0.420 (0.262)			.11
	R2: within	0.184 (N/Ac)		N/A		0.184 (N/A)			N/A
	R2: between	0.01 (N/A)		N/A		0.097 (N/A)			N/A
	R2: overall	0.059 (N/A)		N/A		0.125 (N/A)			N/A
Pain
	Week 0	Ref		Ref		Ref			Ref
	Week 12	0.478 (0.676)		.48		0.478 (0.676)			.48
	Week 24	–0.739 (0.676)		.28		–0.739 (0.676)			.28
	Intervention group	Ref		Ref		Ref			Ref
	Control group	0.459 (0.723)		.53		0.468 (0.737)			.53
	Week 0 × control group	Ref		Ref		Ref			Ref
	Week 12 × control group	0.105 (0.866)		.90		0.105 (0.866)			.90
	Week 24 × control group	0.961 (0.866)		.27		0.961 (0.866)			.27
	R2: within	0.038 (N/A)		N/A		0.038 (N/A)			N/A
	R2: between	0.040 (N/A)		N/A		0.086 (N/A)			N/A
	R2: overall	0.039 (N/A)		N/A		0.064 (N/A)			N/A
Activity
	Week 0	Ref		Ref		Ref			Ref
	Week 12	–1.390 (0.677)		.04		–1.390 (0.677)			.04
	Week 24	–2.350 (0.677)		.001		–2.350 (0.677)			<.001
	Intervention group	Ref		Ref		Ref			Ref
	Control group	0.079 (0.765)		.92		0.393 (0.755)			.60
	Week 0 × control group	Ref		Ref		Ref			Ref
	Week 12 × control group	1.090 (0.867)		.21		1.090 (0.867)			.21
	Week 24 × control group	0.987 (0.867)		.26		0.987 (0.867)			.26
	R2: within	0.144 (N/A)		N/A		0.144 (N/A)			N/A
	R2: between	0.030 (N/A)		N/A		0.157 (N/A)			N/A
	R2: overall	0.082 (N/A)		N/A		0.151 (N/A)			N/A
HECSId
	Week 0	Ref		Ref		Ref			Ref
	Week 12	–0.513 (0.229)		.03		–0.513 (0.229)			.03
	Week 24	–0.715 (0.229)		.002		–0.715 (0.229)			.002
	Intervention group	Ref		Ref		Ref			Ref
	Control group	–0.158 (0.273)		.56		–0.062 (0.254)			.81
	Week 0 × control group	Ref		Ref		Ref			Ref
	Week 12 × control group	0.327 (0.293)		.26		0.327 (0.293)			.26
	Week 24 × control group	0.429 (0.293)		.14		0.429 (0.293)			.14
	R2: within	0.102 (N/A)		N/A		0.102 (N/A)			N/A
	R2: between	0.01 (N/A)		N/A		0.286 (N/A)			N/A
	R2: overall	0.044 (N/A)		N/A		0.211 (N/A)			N/A

^aDLQI: Dermatology Life Quality Index.

^bRef: reference value.

^cN/A: not applicable.

^dHECSI: Hand Eczema Severity Index.