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Schematic representation of the modulation of uterine functions through the estrogen-gut microbiome axis. The secretion of β-glucuronidase by gut bacteria converts conjugated estrogen into deconjugated estrogen in the GI tract. The deconjugated estrogen is reabsorbed by the gut and translocated into the bloodstream, facilitating estrogen entry into the uterus, wherein estrogen exerts its downstream action.
