Skip to main content
. Author manuscript; available in PMC: 2023 Mar 22.
Published in final edited form as: Nat Rev Dis Primers. 2021 Oct 7;7(1):73. doi: 10.1038/s41572-021-00307-9

Figure 8. Diagnostic algorithm for HLH.

Figure 8.

Flow diagram of clinical decision making when confronted with a patient who has signs and symptoms of HLH. aSome patients with genetic predisposition to HLH may develop atypical disease presentations; bIf safe to obtain; cIf not previously performed; dFor example, consider HSV, VZV, HHV6, HIV, Parvovirus, leishmaniasis, tick-borne illnesses, mosquito-borne illnesses, histoplasmosis and TB, amongst others.