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. 2023 Mar 21;13:62. doi: 10.1186/s13578-023-01002-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Identification of enterocyte cell clusters and their expression features. A. tSNE plot of all the enterocyte, colored by different stages. B. tSNE plot of all the enterocyte, colored by clusters. C. tSNE plot of all the enterocyte, colored by different stages and clusters. D. The stacked histogram shows the 11 different cell cluster composition in 3 pathological stages. E. The bar chart shows each enterocyte cell cluster composition of 3 pathological stages. F. The expression of marker genes of the enterocyte cells in different stages. G. Expression-based pathway activities scored by GSVA per enterocyte cluster, the red color indicates enrichment and blue color indicates not enrichment. H. The top marker gene expression and cell location of enterocyte clusters by TCGA and the Human Protein Atlas. I. Violin plots of top marker gene expression in enterocyte clusters