Table 2.

RNA-seq results for TF knockdown experiments in K562. For each TF, we provide the number of statistically significant IR events that are up-regulated (down-regulated), i.e., exhibit increased (decreased) retention with respect to the wild-type. Within the up-regulated events we provide the number of events with occurrences of the motif compared to the background set composed of IR events. This is done in both the intron and the flanking exons. The significance of the difference in the rates of occurrence of the motif is provided in the last column. In all cases the significance was exhibited in the flanking exons, except for E2F4 which exhibited similar levels of significance in both the introns and flanking exons

TF	Up-regulated	Down-regulated	Motif occurrences		p-value
			Intron	Exon
MAZ	69	34	23% (25%)	31% (16%)	0.001
SP1	86	18	69% (64%)	86% (51%)	1.3E−9
SP2	99	25	31% (27%)	41% (16%)	1.4E−9
E2F4	174	58	18% (12%)	18% (11%)	0.008