Table 2.
Cox regression Hazard ratios for serum protein levels, in relation to survival
| Overall survival Hazard ratio (95%CI) |
Progression-free survival Hazard ratio (95%CI) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Serum protein | Unadjusted | P value | q value | Adjusted | P value | q value | Unadjusted | P value | q value | Adjusted | P value | q value |
| ADA | – | – | – | – | – | – |
2.13 (1.46–3.09) |
< 0.0001 | 0.0067 |
2.39 (1.38–4.16) |
0.0020 | 0.1703 |
| CASP8 | – | – | – | – | – | – |
1.65 (1.28–2.14) |
0.00012 | 0.0099 |
1.73 (1.25–2.39) |
0.00087 | 0.0786 |
| CAIX |
1.56 (1.27–1.93) |
< 0.0001 | 0.0017 |
1.44 (1.15–1.81) |
0.0018 | 0.1399 | – | – | – | – | – | – |
| CD244 |
0.57 (0.35–0.95) |
0.030 | 0.9216 |
0.74 (0.37–1.49) |
0.40 | 0.9818 |
0.50 (0.31–0.79) |
0.0028 | 0.2250 |
0.50 (0.27–0.91) |
0.022 | 0.9819 |
| CD8A | – | – | – | – | – | – |
0.91 (0.68–1.22) |
0.55 | 0.9899 |
0.97 (0.64–1.46) |
0.88 | 0.9819 |
| CSF-1 |
11.16 (4.12–30.20) |
< 0.0001 | 0.0002 |
6.05 (1.59–23.00) |
0.0083 | 0.5976 |
4.90 (2.24–10.68) |
< 0.0001 | 0.0059 |
5.00 (1.61–15.54) |
0.0055 | 0.4584 |
| FasL |
0.58 (0.40–0.83) |
0.0031 | 0.1862 |
0.47 (0.30–0.75) |
0.0013 | 0.1060 | – | – | – | – | – | – |
| IL-6 |
1.37 (1.21–1.56) |
< 0.0001 | < 0.0001 |
1.54 (1.14–2.10) |
0.0056 | 0.4126 |
1.26 (1.11–1.43) |
0.00029 | 0.0245 |
1.47 (1.11–1.93) |
0.0068 | 0.5677 |
| IL-8 |
1.47 (1.31–1.66) |
< 0.0001 | < 0.0001 |
1.63 (1.33–1.98) |
< 0.0001 | 0.0002 |
1.35 (1.20–1.53) |
< 0.0001 | 0.0001 |
1.44 (1.18–1.76) |
0.00034 | 0.0310 |
| IL-10 |
1.41 (1.19–1.66) |
< 0.0001 | 0.0058 |
1.42 (1.14–1.77) |
0.0019 | 0.1492 |
1.32 (1.11–1.56) |
0.0015 | 0.1176 |
1.35 (1.11–1.63) |
0.0025 | 0.2114 |
| MCP2 | – | – | – | – | – | – |
0.89 (0.68–1.16) |
0.39 | 0.9899 |
0.88 (0.63–1.24) |
0.47 | 0.9819 |
| MUC16 |
1.40 (1.22–1.61) |
< 0.0001 | 0.0001 |
1.27 (1.05–1.55) |
0.015 | 0.9818 |
1.23 (1.08–1.39) |
0.0014 | 0.1157 |
1.22 (1.02–1.45) |
0.029 | 0.9819 |
| TFNSFR4 |
1.78 (1.29–2.46) |
0.00043 | 0.0307 |
1.99 (1.23–3.23) |
0.0054 | 0.4062 | – | – | – | – | – | – |
The hazard ratio corresponds to a doubling of normalized protein expression values (NPX values), an arbitrary unit on a log2 scale
q values are P values adjusted for multiple comparison (all 92 serum proteins) using false discovery rate (FDR)
– denotes not relevant HRs since these are not top proteins selected for the respective outcome
CI confidence interval