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. Author manuscript; available in PMC: 2023 Mar 22.
Published in final edited form as: Chem Rev. 2020 Nov 24;121(9):5336–5358. doi: 10.1021/acs.chemrev.0c00644

Figure 13.

Figure 13

Mapping of slc29a3 mutations associated with a broad spectrum of genetic disorders onto their corresponding conserved positions in the human ENT1 crystal structure (PDB ID 6OB7; mutation sites highlighted in red, pH sensing residue highlighted in grey). Mutations in human ENT3 are labeled in bold, and the corresponding conserved positions in human ENT1 are listed below in parentheses.