TABLE 4.
Results from the multinomial regression of plasma proteins related to overweight/obese allergic and non‐allergic asthma.
| Overweight/obese allergic asthma (n = 52) | Overweight/obese non‐allergic asthma (n = 21) | |||||||
|---|---|---|---|---|---|---|---|---|
| Protein | RRR (95% CI) | p | RRR (95% CI)adj | padj | RRR (95% CI) | p | RRR (95% CI)adj | padj |
| 4‐EBP1 | 1.0 (0.7,1.3) | 0.798 | 0.9 (0.6,1.3) | 0.547 | 0.6 (0.3,0.9) | 0.022 | 0.6 (0.3,1.0) | 0.063 |
| AXIN‐1 | 1.0 (0.7,1.4) | 0.910 | 1.0 (0.7,1.4) | 0.917 | 0.6 (0.4,0.9) | 0.025 | 0.6 (0.4,1.1) | 0.085 |
| CASP8 | 1.1 (0.7,1.8) | 0.665 | 1.1 (0.7,1.9) | 0.665 | 0.3 (0.1,0.9) | 0.028 | 0.4 (0.1,1.3) | 0.142 |
| CD244 | 1.4 (0.6,3.0) | 0.418 | 1.3 (0.6,2.8) | 0.503 | 0.3 (0.1,1.0) | 0.047 | 0.3 (0.1,1.2) | 0.086 |
| CDCP1 | 1.8 (1.0,3.2) | 0.033 | 1.5 (0.8,2.8) | 0.240 | 2.7 (1.3,5.4) | 0.006 | 1.8 (0.8,4.2) | 0.170 |
| CXCL6 | 1.0 (0.7,1.5) | 0.924 | 1.0 (0.7,1.5) | 0.942 | 0.5 (0.3,1.0) | 0.042 | 0.5 (0.3,1.0) | 0.067 |
| FGF19 | 0.7 (0.5,0.9) | 0.012 | 0.7 (0.5,0.9) | 0.016 | 0.9 (0.5,1.4) | 0.576 | 0.9 (0.6,1.5) | 0.799 |
| FGF23 | 0.7 (0.3,1.4) | 0.307 | 0.5 (0.2,1.2) | 0.106 | 2.2 (1.2,3.9) | 0.011 | 1.8 (0.9,3.5) | 0.081 |
| Flt3L | 1.0 (0.5,2.2) | 0.971 | 0.9 (0.4,1.9) | 0.709 | 3.1 (1.1,9.4) | 0.040 | 1.8 (0.5,6.2) | 0.327 |
| IL‐2 | 0.2 (0.0,1.0) | 0.049 | 0.2 (0.0,0.9) | 0.032 | 0.8 (0.1,8.1) | 0.819 | 0.6 (0.1,7.1) | 0.693 |
| IL‐4 | 0.5 (0.3,0.9) | 0.013 | 0.5 (0.3,0.8) | 0.009 | 1.0 (0.6,1.7) | 0.968 | 1.1 (0.6,2.0) | 0.638 |
| IL‐5 | 1.2 (0.9,1.5) | 0.136 | 1.2 (0.9,1.5) | 0.140 | 1.5 (1.1,1.9) | 0.003 | 1.5 (1.1,2.0) | 0.005 |
| IL‐6 | 1.1 (0.7,1.8) | 0.657 | 0.8 (0.5,1.5) | 0.550 | 2.4 (1.4,4.1) | 0.001 | 2.1 (1.1,3.7) | 0.018 |
| IL‐10RB | 1.5 (0.5,4.8) | 0.485 | 1.1 (0.3,3.8) | 0.826 | 4.9 (0.9,26.3) | 0.067 | 5.5 (0.8,37.6) | 0.083 |
| MCP3 | 1.8 (1.1,2.9) | 0.011 | 1.7 (1.0,2.7) | 0.043 | 1.2 (0.5,2.7) | 0.736 | 0.7 (0.2,1.9) | 0.454 |
| SIRT2 | 1.0 (0.8,1.3) | 0.970 | 1.0 (0.7,1.3) | 0.835 | 0.6 (0.4,0.9) | 0.019 | 0.6 (0.4,1.0) | 0.050 |
| SLAMF‐1 | 1.1 (0.4,3.1) | 0.866 | 1.0 (0.3,2.9) | 0.984 | 0.2 (0.0,0.7) | 0.021 | 0.2 (0.0,0.8) | 0.030 |
| STAMBP | 1.0 (0.7,1.4) | 0.974 | 1.0 (0.7,1.3) | 0.792 | 0.5 (0.3,0.8) | 0.008 | 0.6 (0.3,1.0) | 0.036 |
| uPA | 2.4 (0.9,6.3) | 0.067 | 2.4 (0.9,6.2) | 0.077 | 8.1 (2.3,28.8) | 0.001 | 8.6 (2.3,32.1) | 0.001 |
Note: Reference: overweight/obese controls (n = 390). p‐values <0.05 indicated in bold.
adjModel adjusted for sex, body mass index and body fat percentage.