Table III.

Overview of four clinical trials for the treatment of ankle and hand disorder using decellularized tissue.

Trial no.	Condition	Clinical trial name	Length	Status	Product name	Source tissue	Country	Hospital/Company	Clinical reports	Decellularization method/sterilization method
AH1	Ankle: osteochondral lesions of the talus	OD-PHOENIX in talus osteochondral lesion	2017 to 2021	Terminated (low accrual rate)	OD-PHOENIX	Human osteochondral plug	Belgium, Israel	AZ Monica, Poriya Medical Centre/TBF Genie Tissulaire	N/A	N/A; gamma irradiation (25 to 32 kGy), freezing²³
AH2	Ankle: lateral collateral ligament instability of the ankle	The comparison of clinical and radiological outcomes between modified Broström operation and lateral ankle ligament reconstruction using acellular dermal matrix augmentation in chronic lateral ankle instability: A 5 year randomized controlled trial	2020 to 2025	Recruiting	SureDerm	Human dermis	South Korea	Wonkwang University Hospital/Hans Biomed Corporation	N/A	Enzymes, EDTA/freeze-dried³¹
AH3	Hand: CM arthritis of the thumb	Use of FlexHD as Post Trapeziectomy Spacer	2013 to 2017	Completed	FlexHD	Human dermis	USA	Cedars-Sinai Department of Hand Surgery/Ethicon	Yao³²	Non-ionic surfactant (Triton X-100)/alcohol, peracetic acid³³
AH4	Hand: STT arthritis	Use of a treated, devitalized and sterile meniscus segment (MENISC-T) in the treatment of STT osteoarthritis	2021 to 2023	Recruiting	MENISC-T	Human meniscus	France	Institut Chirurgical de la Main et du Membre Supérieur/TBF Genie Tissulaire	N/A	N/A

CM, carpometacarpal; EDTA, ethylenediaminetetraacetic acid; N/A, not available; STT, scaphotrapeziotrapezoid.