Table 1.
Demographics and Clinical Characteristics
| Adverse events of dissociation | Total N = 764 |
||||
|---|---|---|---|---|---|
| Not reported n = 655 |
Mild n = 78 |
Moderate n = 26 |
Severe n = 5 |
||
| Age (y), mean (SD) | 51.9 (13.7) | 49.5 (13.6) | 48.4 (11.1) | 44.6 (10.6) | 51.5 (13.6) |
| Sex, n (%) | |||||
| Male | 236 (36.0) | 40 (51.3) | 10 (38.5) | 1 (20.0) | 287 (37.6) |
| Female | 419 (64.0) | 38 (48.7) | 16 (61.5) | 4 (80.0) | 477 (62.4) |
| Race, n (%) | |||||
| Asian | 69 (10.5) | 9 (11.5) | 1 (3.9) | 1 (20.0) | 80 (10.5) |
| Black or African American | 14 (2.1) | 1 (1.3) | 0 | 0 | 15 (2.0) |
| White | 553 (84.4) | 67 (85.9) | 25 (96.2) | 4 (80.0) | 649 (85.0) |
| Other/multiple/not reported | 19 (2.9) | 1 (1.3) | 0 | 0 | 20 (2.6) |
| Oral antidepressant, n (%) | |||||
| Duloxetine | 213 (32.6) | 19 (24.4) | 10 (38.5) | 1 (20.0) | 243 (31.9) |
| Escitalopram | 173 (26.5) | 36 (46.2) | 9 (34.6) | 3 (60.0) | 221 (29.0) |
| Sertraline | 130 (19.9) | 17 (21.8) | 3 (11.5) | 1 (20.0) | 151 (19.8) |
| Venlafaxine XR | 138 (21.1) | 6 (7.7) | 4 (15.4) | 0 | 148 (19.4) |
| Age when diagnosed with MDD (y), mean (SD) | 36.0 (13.9) | 32.8 (11.5) | 28.7 (11.0) | 24.0 (5.4) | 35.3 (13.7) |
| Baseline MADRS total score, mean (SD) | 31.3 (5.3) | 30.7 (5.2) | 31.4 (4.6) | 28.4 (2.9) | 31.2 (5.3) |
Abbreviations: MADRS, Montgomery and Åsberg Depression Rating Scale; MDD, major depressive disorder; XR, extended release.