Table 1.

Study design and planned study assessment time points in ADVANCE core and ADVANCE-TBI substudy

		Planned study visit (years post-recruitment)
		0	3	6	10	15	20
ADVANCE	Clinical assessment	x	x	x	x	x	x
	DNA	x	–	–	–	–	–
ADVANCE-TBI substudy	MRI of the brain	–	x	x	x	x	x
	Neuropsychology	–	x	x	x	x	x
	Blood biomarkers	x	x	x	x	x	x

All ADVANCE core assessments are performed for all participants, with ADVANCE-TBI substudy facilitating additional MRI of the brain, neuropsychology and blood biomarker analyses.

‘x’ denotes included; ‘–’ denotes excluded.

ADVANCE, ArmeD SerVices TrAuma and RehabilitatioN OutComE; TBI, traumatic brain injury.