Table 1. Summary of individual image-derived phenotype associations with leucocyte telomere length.
| Imaging modality | IDP type | Location | Association with LTL |
|---|---|---|---|
| T1 |
Global grey matter and CSF volumes | Global | Positive |
| Global white matter volumes | Global | Positive | |
| Regional volumes | Frontal, temporal, thalamus, brainstem, hippocampi, amygdala | Positive | |
| Cortical thickness | Middle and superior frontal sulcus, lingual sulcus, medial occipito-temporal sulcus; Superior temporal gyrus. | Positive | |
| Grey-White Contrast (GWC) | Lingual, pericalcarine, inferior and lateral parietal, precuneus, supramarginal | Negative | |
| T1 and T2-FLAIR | White matter hyperintensity volume | Global and periventricular | Negative |
| swMRI | T2* | Caudate, putamen | Positive |
| Susceptibility | Negative | ||
| dMRI | FA, ICVF, MO | Corpus callosum splenium, sagittal stratum, inferior and superior longitudinal fasiculus, inferior fronto-occipital fasciculus | Negative |
| L1-3, MD, ISOVF | Positive |
Only associations significant after multiple testing correction are included. Abbreviations: FLAIR–fluid-attenuated inversion recovery, swMRI–susceptibility-weighted magnetic resonance imaging, DTI–diffusion tensor imaging, IDP–image-derived phenotype, CSF–cerebrospinal fluid, GWC–grey-white contrast, FA–fractional anisotropy, ICVF–intracellular volume fraction, MO–mode, MD–mean diffusivity, ISOVF–isotropic volume fraction.