Fig 6. Dispersion of H5N1-WT virus variants from nasal turbinates to the CNS.

Unique variants are presented in grey. Common variants between nasal turbinate (NT) and olfactory bulb (OB) are in orange. Common variants between the olfactory bulb and the brainstem (BS) are in green. Common variants between nasal turbinate and brainstem are in white. Variants that are common throughout are in blue. The types of mutation are represented by shapes: synonymous (Syn.) as circles, nonsynonymous (Nonsyn.) as tringles, variants in the untranslated regions (UTR) as diamonds and nonsense as squares. Nucleotide position within the concatenated viral genome is shown on the x-axis. Dashed grey line shows consensus cut off at frequency of 0.5 whereas the dashed black line marks a frequency of 1.