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. 2023 Mar 10;19(3):e1011214. doi: 10.1371/journal.ppat.1011214

Table 2. Clinical signs in H5N1-WT and H5N1-CNS virus inoculated ferrets.

H5N1-WT (No./Total) H5N1-CNS (No./Total)
Days post inoculation 0 1 2 3 4 5 6 0 1 2 3 4 5 6
Respiratory signs
 Sneezing - - 6/6 6/6 3/3 - - - - 6/6 6/6 1/3 - -
 Nasal discharge - - - - - - - - - - - - - -
 Dyspnea - - - - - - - - - - - - - -
 Hunched posture - - - - - - - - 1/3 - - - - -
Systemic signs
 Physical condition N/A N/A N/A Good N/A N/A Moderate 1/3 Poor 1/3 Good 1/3 N/A N/A N/A Good N/A N/A Moderate 1/3 Good 2/3
 Activity score* 0 (6/6) 0 (6/6) 0 (6/6) 0 (6/6) 0 (3/3) 1 (3/3) 2 (2/3) 3 (1/3) 0 (6/6) 0 (6/6) 0 (6/6) 0 (6/6) 0 (6/6) 1 (2/3) 0 (1/3) 0 (1/3) 1 (1/3) 2 (1/3)
 Ruffled fur - - - - - - 3/3 - 3/3 - - - - 3/3
Neurological signs
 Ataxia - - - - - - 3/3 - - - - 1/3 - 2/3
 Parases - - - - - - 3/3 - - - - 1/3 - 2/3
 Tremors - - - - - - 1/3 - - - - - - -

*0: Alert and playful

*1: Alert and playful only when stimulated

*2: Alert but not playful when stimulated

*3: Neither alert nor playful when stimulated

N/A: not applicable