Table 2. Clinical signs in H5N1-WT and H5N1-CNS virus inoculated ferrets.
H5N1-WT (No./Total) | H5N1-CNS (No./Total) | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Days post inoculation | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 0 | 1 | 2 | 3 | 4 | 5 | 6 |
Respiratory signs | ||||||||||||||
Sneezing | - | - | 6/6 | 6/6 | 3/3 | - | - | - | - | 6/6 | 6/6 | 1/3 | - | - |
Nasal discharge | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Dyspnea | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Hunched posture | - | - | - | - | - | - | - | - | 1/3 | - | - | - | - | - |
Systemic signs | ||||||||||||||
Physical condition | N/A | N/A | N/A | Good | N/A | N/A | Moderate 1/3 Poor 1/3 Good 1/3 | N/A | N/A | N/A | Good | N/A | N/A | Moderate 1/3 Good 2/3 |
Activity score* | 0 (6/6) | 0 (6/6) | 0 (6/6) | 0 (6/6) | 0 (3/3) | 1 (3/3) | 2 (2/3) 3 (1/3) | 0 (6/6) | 0 (6/6) | 0 (6/6) | 0 (6/6) | 0 (6/6) | 1 (2/3) 0 (1/3) | 0 (1/3) 1 (1/3) 2 (1/3) |
Ruffled fur | - | - | - | - | - | - | 3/3 | - | 3/3 | - | - | - | - | 3/3 |
Neurological signs | ||||||||||||||
Ataxia | - | - | - | - | - | - | 3/3 | - | - | - | - | 1/3 | - | 2/3 |
Parases | - | - | - | - | - | - | 3/3 | - | - | - | - | 1/3 | - | 2/3 |
Tremors | - | - | - | - | - | - | 1/3 | - | - | - | - | - | - | - |
*0: Alert and playful
*1: Alert and playful only when stimulated
*2: Alert but not playful when stimulated
*3: Neither alert nor playful when stimulated
N/A: not applicable