TABLE 2.
Feature | Frequency | 2-year survival | Cohort's median age, years |
BODE score >7 | 82/469 (17%) [10], 139/625(23%) [11] |
75% [11], 70% [11] | 64 [10], 66 [11] |
Resting hypoxaemia (PO2 ≤55 mmHg) | 81/175 LTx referrals (46%) [12] | 50% (COPD) to 70% (α-1 AD) [13] | 56 [12], 63–73 [13] |
Hypoxaemia on exertion (SpO2 <88%) without resting hypoxaemia | 33/173 (19% in patient using oxygen) [14] | 80% [15, 16] | 56 [14], 68 [16] |
Home noninvasive ventilation | 147/402 LTx referrals(36%) [12] | 65% [17, 18] | 65 [17], 67 [18] |
Exacerbation with hypercapnia | 325/4343 (7%) [19, 20] | 51% [21], 35% [22], 47% [23] | 59 [21], 69 [22], 63 [23], 70 [19, 20] |
≥1 exacerbation with hospitalisation | 105/304 (34%) [24] | 70% [24] | 69 [24] |
FEV1 <20% | 69/1033 (7%) [25] | 80% [25] | 63 [25] |
Mean pulmonary artery pressure ≥35 mmHg | 16/409 (4%) [26], 44/4305 (6%) [27] |
70% [26], 58% [27] | 54 [26], 59 [27] |
BODE: body mass index, obstruction, dyspnoea and exercise capacity score; PO2: oxygen tension; SpO2: peripheral oxygen saturation; FEV1: forced expiratory volume in 1 s; LTx: lung transplantation; α-1 AD: α-1 antitrypsin deficiency.