. Author manuscript; available in PMC: 2024 Apr 1.

Published in final edited form as: J Am Acad Dermatol. 2023 Jan 20;88(4):841–847. doi: 10.1016/j.jaad.2023.01.014

Table 5 –

One-year incidence of inflammatory bowel among patients with acne treated with isotretinoin in comparison to patients with acne treated with oral tetracycline-class antibiotics

	Oral tetracycline-class antibiotics			Isotretinoin			Odds Ratio	95% CI
	Patients, total, n	Patients with incident outcome, n	IR/1000	Patients, total, n	Patients with incident outcome, n	IR/1000	Odds Ratio	95% CI
Outcomes
Any inflammatory bowel disease	11,210	16	1.43	11,199	18	1.61	1.13	0.57–2.21
Crohn’s disease	11,231	12	1.07	11,231	12	1.07	1.00	0.45–2.23
Ulcerative colitis ¹	-	-	-	-	-	-	-	-

Could not accurately estimate since the number of outcomes in the tetracycline group was ≤ 10