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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Nat Struct Mol Biol. 2023 Feb 6;30(3):391–402. doi: 10.1038/s41594-023-00921-z

Figure 1. Biochemical and Structural Overview of Phosphoribosyl Pyrophosphate Synthetase.

Figure 1.

A. Schematic of PRPS catalysis and regulation. B. Backbone trace of a PRPS1 protomer, showing domain organization and residues contributing to allosteric and catalytic sites. C. PRPS1 hexamer, showing how multiple chains contribute to each allosteric and active site.